Clinical Screening · MDQ Framework

Bipolar Test — 15 Questions, MDQ Framework

The most widely used bipolar disorder screening tool. Validated MDQ (Mood Disorder Questionnaire) framework — Hirschfeld et al., 2000. Distinguishes bipolar from unipolar depression. Used in primary care, research, and psychiatric intake worldwide.

Questions

15 items

Framework

MDQ (2000)

Time

3–5 min

Sensitivity

~73%

Screening tool, not a diagnosis. Bipolar disorder is often misdiagnosed as depression in primary care — the right diagnostic clarity matters because treatment differs significantly. If in crisis: 988 (US), 116 123 (UK Samaritans).
Part 1: Manic-spectrum symptoms0% · Question 1 of 15

Has there been a period of time when you were not your usual self, and felt so good or so hyper that other people thought you were not your normal self or you were so hyper that you got into trouble?

Bipolar disorder by the numbers

From NIMH and Kessler et al. epidemiological data.

2.8%

US lifetime prevalence

NIMH

~73%

MDQ sensitivity for bipolar I

Hirschfeld et al.

~90%

MDQ specificity

Hirschfeld et al.

Bipolar I/II

Plus cyclothymic disorder

DSM-5

Methodology & sources

Methodology & sources

Based on
The Mood Disorder Questionnaire (MDQ), the most widely used bipolar disorder self-report screening tool worldwide.
Developed by
Robert Hirschfeld, Janet Williams, and colleagues (2000). Validated against structured clinical interview at the University of Texas Medical Branch.
Validated in
Strong psychometric properties across multiple cultures and populations. Approximately 73% sensitivity, 90% specificity for bipolar I. Widely used in primary care, research, and clinical intake.
Our adaptation
The 15 standard MDQ items with original MDQ scoring logic (7+ manic symptoms + concurrent + impairment = positive screen). No adaptation needed — this is the validated instrument.

Bipolar I vs Bipolar II vs Cyclothymic

The DSM-5 distinguishes three main bipolar-spectrum conditions by severity of elevated-mood episodes.

Bipolar I

Requires at least one full manic episode — 7+ days of elevated/irritable mood + increased energy with significant impairment. Often requires hospitalisation. Lifetime prevalence ~1%.

Bipolar II

Requires hypomanic episodes (≥4 days, milder than mania, without major impairment) + major depressive episodes. Often missed because hypomania can feel like a productive period. As serious as Bipolar I for long-term outcomes. Lifetime prevalence ~1.1%.

Cyclothymic Disorder

Chronic mild mood swings over 2+ years — hypomanic-like symptoms and depressive symptoms that don't meet full episode criteria. Often missed; about 0.4-1% lifetime prevalence.

Bipolar vs unipolar depression

The most important diagnostic distinction in mood disorders. Unipolar depression involves only depressive episodes; bipolar involves both depressive AND manic/hypomanic episodes.

Clues that 'depression' might actually be bipolar

  • Onset in adolescence or early adulthood
  • Strong family history of bipolar disorder
  • Depression that responds poorly to antidepressants — or causes agitation
  • Past periods of unusually high energy, productivity, or decreased sleep need
  • Antidepressants triggering manic-like states
  • Postpartum depression with later mood instability

Treatment approaches

Bipolar disorder requires medication combined with psychotherapy. Sleep regularity is non-negotiable.

Medication

  • ✓ Lithium (gold standard mood stabiliser)
  • ✓ Other mood stabilisers (valproate, lamotrigine)
  • ✓ Atypical antipsychotics (quetiapine, lurasidone)
  • ✓ Antidepressants — used cautiously

Psychotherapy + lifestyle

  • → CBT adapted for bipolar
  • → IPSRT (sleep + rhythm therapy)
  • → Family-Focused Therapy
  • → Sleep regularity (critical)

Further reading & resources

Curated starting points if you want to go deeper than this page.

Book

An Unquiet Mind

Kay Redfield Jamison

The definitive bipolar memoir, by a leading bipolar researcher who herself has bipolar disorder. Required reading.

Book

The Bipolar Disorder Survival Guide

David Miklowitz

Miklowitz is one of the leading bipolar researchers. The most practical book on living with bipolar disorder.

Research

MDQ original paper

Hirschfeld et al., 2000

The original validation paper for the MDQ. Foundational reference.

Website

DBSA (Depression and Bipolar Support Alliance)

The leading US patient organisation. Peer support groups, resources, advocacy.

Website

International Bipolar Foundation

Educational resources and support for people with bipolar disorder and their families.

!

Crisis resources

  • US: 988 (Suicide & Crisis Lifeline)
  • UK: 116 123 (Samaritans)
  • DBSA peer support: dbsalliance.org/support

Frequently asked questions

What is the MDQ?+

The MDQ (Mood Disorder Questionnaire) is the most widely used bipolar disorder screening tool, developed by Robert Hirschfeld and colleagues in 2000. It is a brief, validated 15-item instrument that screens for the manic/hypomanic side of bipolar disorder (which is typically what distinguishes bipolar from unipolar depression). The MDQ has 3 sections: 13 manic-spectrum symptoms (yes/no), whether several occurred during the same time period, and whether they caused significant functional impairment. A positive screen requires 7+ symptoms + concurrent occurrence + moderate-to-serious impairment. The MDQ has approximately 73% sensitivity and 90% specificity for bipolar disorder.

What is bipolar disorder?+

Bipolar disorder is a serious mental health condition characterised by significant mood episodes — periods of elevated mood (mania or hypomania) alternating with periods of depression, with periods of normal mood in between. The DSM-5 distinguishes Bipolar I (involves full manic episodes, typically lasting at least a week and often requiring hospitalisation), Bipolar II (involves hypomanic episodes — milder, shorter, not causing severe impairment — plus depressive episodes), and Cyclothymic Disorder (chronic mild mood swings over years). Bipolar disorder affects about 2.8% of US adults across a lifetime; rates are similar across men and women. It typically begins in late adolescence or early adulthood. Bipolar disorder is one of the most under-diagnosed conditions in primary care — often misdiagnosed as depression because patients usually present during depressive episodes.

What's the difference between bipolar I and bipolar II?+

The distinction is the severity of the elevated mood episodes. Bipolar I requires at least one full manic episode — defined as 7+ days (or any duration if hospitalisation required) of significantly elevated/irritable mood plus increased energy, with significant impairment in functioning. Symptoms typically include grandiosity, decreased need for sleep, racing thoughts, increased goal-directed activity, and high-risk behaviour. Bipolar II requires hypomanic episodes (similar symptoms but lasting at least 4 days, less severe, without significant functional impairment) plus major depressive episodes. Bipolar II is often under-diagnosed because hypomanic episodes can feel like positive periods rather than illness, and patients typically only seek help during depressive episodes. Bipolar II is genuinely as serious as Bipolar I in terms of suicide risk and long-term functional impact.

How is bipolar disorder treated?+

Bipolar disorder requires medical treatment combined with psychotherapy. Medication: mood stabilisers (lithium remains the gold standard, despite many newer options), often combined with atypical antipsychotics; antidepressants are used cautiously because they can sometimes trigger manic episodes. Psychotherapy: CBT adapted for bipolar disorder, Interpersonal and Social Rhythm Therapy (IPSRT — Frank), Family-Focused Therapy. Lifestyle: sleep regularity is critical (sleep disruption is one of the strongest triggers of mood episodes); avoiding substance use; recognising early warning signs of episodes. With appropriate treatment, most people with bipolar disorder live full, functional lives — though management is typically lifelong rather than time-limited.

How is bipolar different from depression?+

Unipolar depression involves only depressive episodes; bipolar disorder involves both depressive AND manic/hypomanic episodes. This distinction matters significantly for treatment — antidepressants alone can sometimes trigger manic episodes in bipolar patients, so getting the diagnosis right matters. Clues that depression might actually be bipolar: depression that started in adolescence or early adulthood, depression with strong family history of bipolar, depression that responds poorly to antidepressants or causes activation/agitation, periods of unusually high energy or productivity that don't feel like 'recovery' but more like a different state, episodes of decreased need for sleep that didn't cause fatigue. If any of these apply, the MDQ screen is worth taking — and the result should inform discussion with your prescriber.

What is a manic episode like from the inside?+

Manic episodes are often described as initially feeling exhilarating — high energy, racing thoughts, decreased need for sleep, increased confidence, intensified creativity, and a sense of being able to do anything. Many people in manic episodes report not recognising the state as illness at the time. As the episode progresses, judgment deteriorates: high-risk behaviour (spending sprees, risky sex, impulsive decisions), irritability and conflict, racing thoughts that become hard to follow, and sometimes psychotic symptoms (delusions, hallucinations) in severe cases. The crash into depression after a manic episode is often the trigger for seeking treatment. Hypomanic episodes (in bipolar II) are similar but milder — often feeling like a 'productive period' rather than illness. The retrospective recognition that 'this was actually hypomania' is often a significant moment in bipolar diagnosis.

Can bipolar disorder be cured?+

Bipolar disorder is currently considered a lifelong condition that can be effectively managed but not cured. With appropriate treatment, most people achieve good control of mood episodes and live full, functional lives — many achieve sustained periods of stability (years to decades) without significant episodes. The treatment goal is not the elimination of bipolar disorder but the prevention of episodes, the early intervention when symptoms appear, and the maintenance of functioning. Many high-achieving people across all fields have bipolar disorder and live productive lives with appropriate treatment. The most important predictors of good outcome are early diagnosis, treatment adherence (particularly medication consistency), sleep regularity, and avoiding substance use.